She became the first female rapper nominated for an Academy Award (for 2002's Chicago); Her third album, Black Reign, was the first album by a female MC ever to go gold; And The Queen Latifah Show, which debuted in 1999, was the first daytime talk show hosted by a Hip Hop artist.
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Latifah had this to say about the accopmlishment: "I think the reason I am here is to inspire African-American women who are rappers, full-figured women to know that they can do it, too."
Latifah's latest film, The Last Holiday, co-starring LL Cool J, opens in theaters January 13th.